There is research which suggests that 5-MeO-DMT could have associations with improvements in anxiety and depression. It is sometimes used as an adjunct to Ibogaine therapy for the treatment of addiction. This may be effective because 5-MeO-DMT has been shown to down-regulate a receptor involved in the mechanism of drug abuse. The same study found that cells treated with 5-MeO-DMT show a similar response to medications. Further research is needed to investigate 5-MeO-DMT’s potential anti-depressive properties.
There have been suggestions that NN DMT could be of use in understanding the neurobiological basis of hallucinations and for antipsychotic drug development.
Can NN DMT be mixed with other drugs?
There is evidence to show that mixing NN DMT with MAOI drugs can be dangerous and increase the risk of harm. As NN DMT is active in doses from as small as 3mg, to avoid accidental overdose.
There is also an increased risk of cardiac complications if combined with stimulants.
Alcohol should also be avoided to reduce the risk of vomiting and aspiration.
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Is NN DMT addictive?
A study of NN DMT users concluded that it is used predominantly for spiritual exploration’ and ‘has a low potential for addiction’. 82% of the sample reported using DMT for spiritual or healing/psychological purposes, indicating that it is not a substance that is commonly used recreationally.
Additionally, the majority of the sample indicated that they used it less than once a year, with the majority of use taking place in ceremonial contexts. Therefore, compulsive re-dosing and addictive behavior patterns are unlikely to be seen with 5-MeO-DMT.
Psychological effects
DMT is rapidly acting and effects are typically observed around 2-5 minutes after consumption and last around 15-20 minutes. Despite its short-lived effects, DMT is known as one of the most powerful psychedelic drugs. The subjective effects of DMT can often be meaningful but will vary with dosage. These include:
- Eliciting intense visual alterations and hallucinations, specifically colourful and geometric forms
- Profound spiritual or mystical experiences
- Varying alternations in mood and emotion, including experiences of euphoria, calm, fear and anxiety
- Perceived encounters with external entities, which are often described as elf-like.
- Altered sense of time and place
- A sense of depersonalisation or out of body experiences
- Potential auditory hallucinations
- Evocation of powerful memories
Physiological effects
DMT is associated with low toxicity and is easily metabolised by the body. However, there are physiological implications and associated risks to be aware of. These include elevated blood pressure and increased heart rate, which is particularly risky for those with heart conditions. The impaired cognitive and motor function poses a personal safety risk and presents further reason for DMT to be consumed in a safe environment with a sober sitter. It should be noted that at high doses there are some reports of seizures, respiratory effects and comas.
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